Our funding themes
Five questions we’re working on.
We fund research that detects and prevents dementia before it begins – from near-application markers to bold, early ideas.
Closer to application
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01
Near-application
Plasma biomarkers: p-tau217 & Aβ42/40
“Can Alzheimer’s be detected in the blood before symptoms appear?”
We fund validation of blood markers for presymptomatic early detection.
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02
Near-application
Precision prevention: APOE status & polygenic risk score
“Which prevention fits which risk?”
We fund stratification from genetics, biomarkers and lifestyle.
Early & experimental
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03
Highly experimental
Infection hypothesis: herpes zoster vaccination (VZV)
“Can a vaccination lower dementia risk?”
We fund the missing randomized prevention trial.
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04
Highly experimental
Resilience genetics: APOE3-Christchurch & ε2 gene therapy
“What protects some people from birth?”
We fund research into natural protective variants.
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05
Experimental
Glymphatic clearance during deep sleep
“How does the brain clean itself during sleep — and can that be strengthened?”
We fund research into the brain’s self-cleansing during sleep.